June 12, Wednesday

10:00          

Registration

10:45- 11:00   

Opening

11:00- 12:55

Session 1: Membrane proteins and cellular aspects

Chairs:

Peter Nagy, University of Debrecen

György Vámosi, University of Debrecen

Mario Brameshuber

MONTE CARLO SIMULATIONS FOR THE EVALUATION OF

QUANTITATIVE SINGLE MOLECULE FLUORESCENCE MICROSCOPY

Aleš Iglič 

ON THE ROLE OF ACTIN FORCES AND PROTEIN INTRINSIC CURVATURES

IN PHAGOCYTOSIS AND MIGRATION OF CELLS ON CURVED SURFACES

Jerker Widengren (on-line)

FLUOROPHORE BLINKING – A SOMEWHAT OVERLOOKED SOURCE OF

INFORMATION FOR BIOMOLECULAR AND CELLULAR STUDIES

Hector Martinez-Seara 

ENHANCING ELECTROSTATIC INTERACTION MODELS THROUGH ELECTRONIC POLARIZATION:INSIGHTS FROM THE PROSECCO75 BIOMOLECULAR

FORCE FIELD

Zsolt Török  

MILD HYPERTHERMIA INDUCED INTRACELLULAR THERMOGENESIS DEFINES

STRESS RESPONSE MECHANISMS 

12:55-14:00

Lunch 

14:15- 15:50

Session 2: Extracellular vesicles

Chairs:

Edit Buzás, Semmelweis University

Veronika Iglič, University of Ljubljana 

Veronika Kralj-Iglic 

ASSESSMENT OF NUMBER DENSITY AND SIZE OF EXTRACELLULAR PARTICLES IN DIFFERENT BIOLOGICAL FLUIDS WITH INTERFEROMETRIC LIGHT MICROSCOPY 

Tamás Beke-Somfai 

RED BLOOD CELL DERIVED VESICLES AS INTERACTING PARTNERS OF

AMPHIPHILIC ANTIMICROBIAL PEPTIDES

Tamás Visnovitz 

RELEASE OF EN BLOC SECRETED AMPHIECTOSOME-DERIVED SMALL

EXTRACELLULAR VESICLES 

Bartosz Różycki  

MEMBRANE CURVATURE SENSING BY MODEL BIOMOLECULAR CONDENSATES

Bio-Science Ltd, Sinkó Emese 

SHIFT PERSPECTIVE, ACHIEVE MORE: INTRODUCING THE CYTOFLEX NANO FLOW CYTOMETER 

15:50- 16:30 

Coffee break

16:45- 17:15

Pleanary lecture I. Chair: Stefan Knippenberg

John Seddon, Imperial College, UK

INVERSE BICONTINUOUS AND DISCONTINUOUS PHASES OF LIPIDS

17:30-19:00

Poster session I.

19:00-21:00 

Dinner 

June 13, Thursday

08:45-09:30 

Plenary lecture II. Chair: Aleš Iglič

Douglas Kell, University of Liverpool, UK

A PROTET-BASED MODEL FOR OXIDATIVE AND PHOTOSYNTHETIC PHOSPHORYLATION

09:30-11:10 

Session 3: Lipid protein interactions

Chairs:

John Seddon, Imperial College, UK

Sandro Keller, University of Graz

Ana Nicoleta Bondar 

PROTONATION-COUPLED WATER-MEDIATED HYDROGEN BOND NETWORKS FOR SIGNALING ACROSS CELLULAR MEMBRANES 

Alessandra Luchini  

UNDERSTANDING PROTEIN-LIPID INTERACTIONS ASSOCIATED WITH THE

MALARIA INFECTION 

Tamás Földes

COARSE-GRAINED MOLECULAR DYNAMICS MODELLING OF HUMAN LOW-DENSITY LIPOPROTEIN

Nicolas Carvalho  

DECIPHERING INTERDOMAIN ALLOSTERIC EFFECTS ON THE pH-DEPENDENT

MEMBRANE INSERTION PROCESS OF THE DIPHTHERIA TOXIN 

Marketa Paloncyova  

INTERACTIONS OF CARBON NANOMATERIALS WITH LIPID MEMBRANES 

11:10-11:40                 

Coffee break

11:40-13:20

Session 4: Membrane structure, curvature and dynamics

Chairs:

Hector Martinez-Seara, Czech Academy of Sciences

Marketa Paloncyova, Palacký University

Alex Bunker

THREE VERY DIFFERENT EXAMPLES OF MEMBRANE SIMULATIONS IN

PHARMACEUTICAL RESEARCH

Dominique J. Bicout  

THE DYNAMICAL MATRYOSHKA MODEL OF LIPID BILAYERS 

Marion Alix 

AOC3 ACTIVE SITE ACCESSIBILITY AND HELICES DIMERIZATION

REVEALED BY MEMBRANE MOLECULAR DYNAMIC 

Denys Biriukov 

ULTRA-LARGE-SCALE ALL-ATOM MOLECULAR DYNAMICS SIMULATIONS OF

CELLULAR MEMBRANES AND EXTRACELLULAR INTERACTIONS

Silvio Osella 

PHOTOPHYSICS IN BIOMEMBRANES: COMPUTATIONAL INSIGHT INTO

THE INTERACTION BETWEEN LIPID BILAYERS AND CHROMOPHORES 

13:20-14:30

Lunch 

14:30-16:25

Session 5: Non-bilayer membrane structures

Chairs:

Győző Garab, Biological Research Center

Judith Peters, Grenoble Alpes University

Edward Gasanoff 

AN UPGRADE ON THE PROTON CIRCUIT IN THE INNER MITOCHONDRIAL
MEMBRANE THAT INVOLVES FORMATION OF NON-BILAYER INVERTED MICELLES

Bence Fehér

MOLECULAR DYNAMIC SIMULATION OF LIPID ASSEMBLIES

MIMICKING THYLAKOID MEMBRANES

Ondrej Dlouhy  

LIPID POLYMORPHISM OF PLANT THYLAKOID MEMBRANES –

INSIGHT INTO THE INVERTED HEXAGONAL PHASE 

Judith Peters 

NEUTRON AND X-RAY SCATTERING STUDIES OF
NON-BILAYER MEMBRANE STRUCTURES

Kinga Böde  

LIPID POLYMORPHISM IN PHOTOSYNTHETIC MEMBRANES.
THE FUSION OF PHOTOSYSTEM-II ENRICHED MEMBRANE PAIRS,
ASSISTED BY ISOTROPIC LIPID PHASE 

Győző Garab

THE WHYS AND WHEREFORES OF NON-BILAYER LIPID PHASES IN
ENERGY-CONVERTING BIOLOGICAL MEMBRANES –
CO-CHAIR’S CONCLUDING COMMENTS AND HYPOTHESES

16:25-18:25

Poster session II.

19:00-19:30

Concert of the Debrecen Dixiland Jazz Band at Hotel Divinus

19:30-

Gala dinner at Hotel Divinus

June 14, Friday

08:45-09:30

Plenary lecture III. Chair: Dominique J. Bicout

Amitabha Chattopadhyay, Center for Cellular and Molecular Biology, India

G PROTEIN-COUPLED RECEPTORS AND CHOLESTEROL SENSITIVITY:
EXCITEMENTS AND CHALLENGES

09:30-11:30

Session 6: Membrane mimetics

Chairs:

Norbert Kučerka, Comenius University

Daniela Uhrikova, Comenius University

Petra Pullmanova

LIPID BIOPHYSICS - THE INDISPENSABLE SKIN LIPID BARRIER 

Hanne Antila 

INTRODUCING THE NMRLIPIDS DATABANK:

A GATEWAY TO LARGE-SCALE ANALYSIS OF MEMBRANE SIMULATIONS

Adam Tywoniak  

INVESTIGATION OF DRUG-MEMBRANE INTERACTIONS BY NEW LIPOSOMAL
CO-PERMEATION ASSAY

Daniela Uhríková  

EXOGENOUS LUNG SURFACTANT INTERACTIONS WITH LIPOPOLYSACCHARIDE

AND POLYMYXIN B AS SEEN THROUGH NEUTRON DIFFRACTION

Petra Čechová 

MECHANISTIC INSIGHTS INTO INTERACTIONS BETWEEN IONIZABLE LIPID

NANODROPLETS AND BIOMEMBRANES 

11:05-11:35

Coffee break

11:35-13:35

Session 7: Membrane active peptides, cell penetrating peptides 

Chairs:
István Mándity, Semmelweis University
Ines Neundorf, University of Cologne

Monika Wojciechowska

IMPROVING THE PROPERTIES OF MEMBRANE-ACTIVE PEPTIDES BY

STABILIZING THEIR SECONDARY STRUCTURES 

Evgeniya Save-Trofimenko  

CELL-PENETRATING PEPTIDE UPTAKE AND TRAFFICKING IN CELLS 

Christopher Aisenbrey  

DISTRIBUTION OF TWO SYNERGISTIC ANTIMICROBIAL PEPTIDES ON THE
LIPID MEMBRANE SURFACE AND SIDECHAIN DYNAMICS:A FLUORESCENCE STUDY

Tamás Kovács 

INVESTIGATION OF THE EFFECTS OF SH-42, A POTENTIAL STATIN SUBSTITUTE,

ON MEMBRANE BIOPHYSICAL PARAMETERS AND PENETRATIN UPTAKE

Olivér Pavela  

EXAMINING THE MEMBRANE PERTURBING EFFECT OF THE ANTIFUNGAL

PEPTIDE NFAP2 WITH MOLECULAR DYNAMICS SIMULATIONS 

Wojciech Bal  

SDS MODEL FOR ENHANCED CU(II) DELIVERY TO CELLS BY

AMPHIPHILIC PEPTIDES 

13:35

Closing

13:45-14:45

Lunch

June 27 Monday

14:30-15:00 

 Pavel Jungwirth
Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic

How can cell penetrating peptides enter via membrane fusion?

15:00-15:30

Adela Melcrova
University of Groningen, Netherlands

Lateral membrane organization identified as antimicrobial target

15:30-16:00

Radek Sachl
J. Heyrovsky Institute, Prague, Czech Republic

In-membrane protein oligomerization as a critical step for membrane pore formation

16:00-16:30

Coffee break

16:30-17:00

Jorge Bernardino de la Serna
Imperial College London, UK

Adaptive Lipid Immiscibility and Membrane Remodelling drives Primary Ciliogenesis

17:00-17:30

Roman Pleskot
Institute of Experimental Botany, Prague, Czech Republic

A role of the TPLATE complex in plant endocytosis

17:30-18:00

Cristina Garcia-Mouton
Universidad Compultense Madrit, Spain

Pulmonary surfactant-mediated delivery of peptide through air-liquid interfaces

18:00-18:20

Semen Yesylevskyy
Institute of Physics of the NAS of Ukraine

Enforcing membrane curvature in MD simulations with EnCurv algorithm

18:30-21:00

Poster Session

June 28 Tuesday

 Edward Lyman
University of Delaware, USA

Connecting lipid chemistry to the continuum via molecular simulations

09:45-10:15

Stefan Knippenberg
Hasselt University, Belgium

Multiscale modeling shows that optical properties of molecular probes reveal the phases of surrounding lipid membranes

10:15-10:30

Itay Schachter
Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic

Elastic Theory of Confined Monolayers Well Describes Lipid Nanodiscs

10:30-11:00

Coffee break

11:00-11:30

Kvido Strisovsky
Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic

Mechanism of intramembrane proteolysis

11:30-12:00

Győző Garab
Biological Research Centre, Szeged, Hungary

Structural entities associated with different lipid phases of plant thylakoid membranes – selective susceptibilities to different lipases and proteases

12:00-12:30

Martin Potocký
Institute of Experimental Botany, Prague, Czech Republic

Membrane recruitment of the exocyst complex as a model system for studying lipid-protein interfaces in plant cell polarity

12:30-14:00

Lunch break

14:00-14:45

Ünal Coskun
Center of Membrane Biochemistry and Lipid Research TU Dresden, School of Medicine, Dresden, Germany

The membrane holds the key to understand cell signalling

14:45-15:15

Roland Faller
University of California, Davis, USA

The impact of surface polarity on lipid assembly under spatial confinement

15:15-15:45

Waldemar Kulig
Univeristy of Helsinki, Finland

Are GPCR-lipid interactions optimized for physiological temperature?

15:45-16:00

Maria Chiara Saija
J. Heyrovsky Institute of Physical Chemistry, Prague, Czech Republic

Topical drug delivery into the tear film: A computational study

16:00-16:30

Coffee break

16:30-17:00

Alex Bunker
Univeristy of Helsinki, Finland

Lipid Membrane simulation as a drug design tool: PKC activation as case study, among other examples

17:00-17:30

Markéta Paloncýová
Czech Advanced Technology and Research Institute (CATRIN), Palacký University Olomouc, Czech Republic

Atomistic View into Hexagonal Phase RNA Loaded Lipid Nanoparticles and their pH Dependent Morphology

17:30-18:00

Magdalena Przybylo
Wroclaw Univeristy of Science and Technology, Poland

Liposomal Drug Delivery Systems - from theory to applications

18:00-18:45

Organized trip to the conference dinner venue

June 29 Wednesday

09:00-09:45

 Martin Hof
J. Heyrovsky Institute, Prague, Czech Republic

Lipid driven nanodomains are fluid and interleaflet coupled

09:45-10:15

Christopher Aisenbrey
CNRS/Université de Strasbourg UMR7177, France

Characterization of the interaction of the heptad repeat 1 and 2 regions in the spike protein of SARS-CoV 2 by fluorescence methods

10:15-10:30

Denys Biriukov
Institute of Organic Chemistry and Biochemistry, Prague, Czech Republic

Molecular Simulations of Lipid Membranes: Leaving Equilibrium and Comfort Zone

10:30-10:45

Alejandro Alonso
Complutense University of Madrid, Spain

Surfactant protein SP-B and monolayer/membrane-protein interactions

10:45-11:15

Coffee break

11:15-11:45

Ramachandra M. Bhaskara
Institute of Biochemistry II, Goethe University Frankfurt, Germany

Molecular events during selective ER-Phagy

11:45-12:15

Mario Vazdar
University of Chemistry and Technology, Prague, Czech Republic

Arginine-rich peptides at biological membranes - insights from simulations and experiments

12:15-12:30

Discussion: The future of membranes

Chairs: Hector Martinez-Seara & Lukasz Cwiklik

12:30-12:45

EJTEMM 2024

Wednesday 7th April 2021

 13:45-14:30: EJTEMM 2021 Opening
Sandro Keller and Georg Pabst

13:45 - 14:00
Welcome

14:00-14:30: Opening Lecture
Anthony Watts (University of Oxford, UK)
"The importance of water in membrane receptor function"

14:30-16:30: Complex Biomembrane Mimetics
Chairs: Marta Pasenkiewciz-Gierula and Norbert Kucerka

14:30-15:00
Rumiana Dimova (Max Planck Institute of Colloids and Interfaces, Germany)
"Remodeling of artificial cells: to bud or not to bud"

15:00-15:15
Valeria Rondelli (Università degli Studi di Milano, Italy)
"Fusion mechanisms of small extracellular vesicles with model plasma membranes"

15:15-15:30
Morits P. K. Frewein (University of Graz, Austria)
"Interdigitation-induced interleaflet coupling in asymmetric liposomes"

15:30-15:45
Markéta Paloncýová (CATRIN, Czech Republic)
"Individual role of artificial lipids in mRNA vaccines"

15:45-16:00
Roland FAller (UC Davis, CA)
"Controlling lipid printing"

16:00-16:30
Siewert jan Marrink (University of Groningen, The Netherlands)
"Modeling complex cell membranes"

16:30-17:00: Coffee break

17:00-19:00: Membrane Curvature
Chairs: Alex Bunker and Hector Martinez-Seara

17:00-17:30
Patricia Bassereau (Institut Curie, France)
"Membrane curvature influences (or not...) protein distribution and function"

17:30-17:45
Anand Srivastava (Indian Institute of Science, India)
"Membrane remodeling due to mixture of multiple curvature proteins"

17:45-18:00
Danijela Bakaric (Ruder Boskovic Institute, Croatia)
"Undulations of phoshatidylcholine lipid bilayers with incorporated palmitic acid are blurred by lateral proton transfer"

18:00-18:15
Sebastian Himbert (McMaster University, Canada)
"The nanoscopic bending rigidity of red blood cell membranes"

18:15-18:30
Luka Mesarec (University of Ljubljana, Slovenia)
"Stable discocyte shapes of normal red blood cells explained by membrane's in-plane ordering"

18:30-19:00
Primoz Ziherl (Jozef Stefan Institute, Slovenia)
"Vesicle self-replication and aggregation"

Thursday 8th April 2021

10:00-12:00 Non-lamellar phases
Chairs: Michael Rappolt & Georg Pabst

10:00-10:30
John Seddon (Imperial College, UK)
"Complex non-lamellar inverse phases of lipids"

10:30-10:45
Andrea Ridolfi (CSGI, Italy)
"Development and structural characterization of inverse bicontinuous cubic phase lipid films"

10:45-11:00
Shuo Qian (ORNL, TN)
"Water distribution in a fusogenic lipid membrane from grazing-angle neutron diffraction"

11:00-11:15
James Jennings (University of Wisconsin-Madison, WI)
"Protonation-driven self-assembly of synthetic six-tail lipid A mimics"

11:15-11:30
Ondrej Dlouhy (University of Ostrava, Czech Republic)
"Lipid polymorphism of subchloroplast membrane particles: isolated granum and stroma thylakoids"

11:30-12:00
Erik Lindahl (Stockholm University, Sweden)
"Formation and permeability of the statum corneum"

12:00-14:00: Lunch Break

14:00-16:00: Poster Session 1

16:00-18:00: Lipid/Protein Interactions
Chairs: Michal Otyepka and Sandro Keller

16:00-16:30
Alessandra Luchini (Paul Scherrer Institute, Switzerland)
"Investigating membrane proteins with neutron reflectometry"

16:30-16:45
Roberto Covino (Frankfurt Institute for Advanced Studies, Germany)
"AI-driven computer simulations discover mechanisms of transmembrane assembly"

16:45-17:00
Christopher Kelly (Wayne State University, MI)
"Nanoscale membrane curvature sorts lipid phases and alters lipid diffusion"

17:00-17:15
Hector Martinez-Seara (Czech Academy of Sciences, Czech Republic)
"Improving CHARMM36 simulations by reintroducing the missing electronic polarizability: prosECCo"

17:15-17:30
Nina Gubensäk (University of Graz, Austria)
"Structural insights into the gram-negative lipid transporter YrbC of hämophilus influenzae"

17:30-18:00
Robert Vacha (CEITEC, Czech Republic)
"Enhanced translocation of amphiphilic peptides across membranes by transmembrane proteins"

18:00-20:00: Dinner break

20:00-22:00: Poster session 2

Friday 9th April 2021

10:00-11:30: Lipid droplets and monolayers
Chairs: Martin Hof and Lukas Cwiklik

10:00-10:30
Sylvie Roke (Ecole Polytechnique Fédérale de Lausanne, Switzerland)
"Molecular level probing and quantification of lipid droplet, liposome and liquid condensate interfces in aqueous solution, using nonlinear light scattering"

10:30-10:45
Fabio Strati (Martin Luther University Halle-Wittenberg, Germany)
"Stratum corneum vesicles as promising strategy to treat skin diseases"

10:45-11:00
Candelaria Cámara (Universidad Nacional de Córdoba, Argentina)
"Dexamethasone and dexamethasone phosphate and their effects on DMPC membrane models"

11:00-11:30
Luca Monticelli (CNRS, France)
"Molecular simulations of lipids droplets"

11:30-13:00: Poster session 3

13:00-14:00: Lunch break

14:00-15:30: Membrane active peptides
Chairs: Nermina Malanovic and Burkard Bechinger

14:00-14:30
Miguel Castanho (Instituto de Medicina Molecular, Portugal)
"Diffusion-lysis coupling of antimicrobial peptides in biofilms of S. aureus"

14:30-14:45
Adéla Melcrová (University of Groningen, The Netherlands)
"An unexpected molecular mechanism unveils the functioning of peptidomimetics as antimicrobials"

14:45-15:00
Enrico F. Semeraro (University of Graz)
"Partitioning and in-situ kinetics of lactoferricin derived antimicrobial peptides in Escherichia coli"

15:00-16:00: Coffee break

16:00-17:15: Membrane active peptides
Chairs: Dagmar Zweytick and Alexander Lyubartsev

16:00-16:30
Lorenzo Stella (Université di Roma Tor Vergata, Italy)
"A journey in the complex world of host defense peptides: from in silico to cellular studies"

16:30-16:45
Mariana Valério (Universidade Nova de Lisboa, Portugal)
"Parainfluenza fusion peptide forms oligomeric pore-like structures inside a membrane"

16:45-17:00
Barbara Claro (Universidade do Porto, Portugal)
"Self-assembling of antimicrobial cyclic peptides at model membranes: nanotubes or micellar aggregates?"

17:00-17:15
Morane Lointier (Université de Strasbourg, France)
"Peptide supramolecular assembly as a determinant of biological function"

17:15-18:00: EJTEMM 2021 Closing

17:15-17:45 : Closing lecture
Jesus Perez-Gil (Universidad Computense, Spain)
"Structure-function determinants in pulmonary surfactant protein SP-B, a crucial protein for breathing"

17:45-18:00: Famous last words

Wednesday 12th December 2018

 13:15-13:30
EJTEMM 2018 Opening

Session1: Chair: Alex Bunker

13:30-14:15
Mikko Karttunen (University of Western Ontario, Canada)
"Computer simulations and membranes: drug delivery using pac-man like molecules and other stories"

14:15-15:00
Yvonne Perrie (University of Strathclyde, Scotland)
"Scale-independent production of nanomedicines"

15:00-15:30: Coffee break

Session 2: Krzysztof Murzyn

15:30-16:00
Hector Martinez-Seara (Czech Academy of Sciences, Czech Republic)
"Sodium and calcium cations interactions with neutral phospholipid membranes and how to correctly simulate them"

16:00-16:20
Fabio Lolicato (University of Helsinki, Finland)
"The role of temperature and lipid composition in modulating the interaction of gold nanoparticles with model membranes"

16:20-16:40
Rachel Donaghey (University of Strathclyde, Scotland)
"Effect of microfluidizer pressure and cycle number on AmB-liposome homogenisation and amphotericin B incorporation"

17:00-19:30
Poster session

Thursday 13th December 2018

Session 3: Marta Pasenkiewicz-Gierula

09:00-09:45
Sir John E. Walker (MRC Mithochondrial Biology Unit, United Kingdom)
"Regulation, functional analysis and assembly of dimeric ATP synthases in mitochondria: the involvement of cardiolipin"

09:45-10:30
Pavel Jungwith (Czech Academy of Sciences, Czech Republic)
"Cell penetration and membrane fusion: two sides of the same coin"

10:30-11:00: Coffee break

Session 4: Florent Di Meo

11:00-11:30
Karel Berka (Palacký University Olomouc, Czech Republic)
"MolMeDB - Molecules on membranes database"

11:30-11:50
Daniela Uhrikova (Comenius University in Bratislava, Slovakia)
"Antimicrobial agents targeting phospholipid bilayer"

11:50-12:10
Radek Sachl (Czech Academy of Sciences, Czech Republic)
"Distinct roles of SNARE-mimicking lipopeptides during initial steps of membrane fusion"

12:10-13:40: Lunch

Session 5: Stefan Knippenberg

13:40-14:25
Wataru Shinoda (Nagoya University, Japan)
"Coarse-grained molecular simulation study of liposomal stability"

14:25-14:55
Mohsen Sadeghi (Freie Universität Berlin, Germany)
"Particle-based membrane model for large-scale reaction-diffusion simulations"

14:55-15:15
Lukasz Cwiklik (Czech Academy of Sciences, Czech Republic)
"Surface roughness and palmitoylation of transmembrane helices influence membrane properties"

15:15-15:45: Coffee break

Session 6: Johana Kuncova-Kallio

15:45-16:05
Remigiusz Worch (Polish Academy of Sciences, Poland)
"N-terminal charge and C-terminal residues of influencza fusion peptide are essential for membrane fusion"

16:05-16:25
Petra Cechova (Palacky University/Uniersity of Limoges, Czech Republic/France)
"Xenobiotics transport through membrane proteins (ABC and SLC): A molecular dynamics simulation"

16:25-17:00: Sponsor session

17:00-19:30: Poster session

20:00-23:30: Meeting dinner

Friday 14th December 2018

Chair 7: Tapani Viitala

09:00-09:45
Roland Faller (UC Davis, USA)
"Model development for multiscale modeling of lipids and their interactions"

09:45-10:30
Fredrik Höök (Chalmers University of Technology, Sweden)
"Single nanoparticle analytics: from viruses via exosomes to drug carriers"

10:30-11:00: Coffee break

Session 8: Norbert Kucerka

11:00-11:30
Samuli Ollila (Czech Academy of Sciences/University of Helsinki, Czech Republic/Finland)
"Combining NMC Experiments and MD simulations with open collaboration to model complex biomembranes"

11:30-11:50
Inna Ermilova (Stockholm University, Sweden)
"Computer assisted drug design: first steps towards simulating drug targets against Alzheimer's disease"

11:50-12:10
Ivo Vinklárek (Czech Academy of Sciences, Czech Republic)
"Are nanodomains inter-leaflet coupled? An MC-FRET study"

12:10-13:40: Lunch

Session 9: Patrick Trouillas

13:40-14:25
Martin Hof (Czech Academy of Sciences, Czech Republic)
"How relevant are experimentally determined "in-membrane" oligomerization numbers of proteins for their function? A lesson from the Fibroblast Growth Factor 2"

14:25-14:55
Markéta Paloncýová (KTH Royal Institute of Technology, Sweden)
"Effect of lipid phase on the fluorescent and non-linear optical properties of membrane probes"

14:55-15:15
Petteri Parkkila (University of Helsinki, Finland)
"Partitioning of catechol derivatives in supported lipid bilayers: implications for neurotransmitter metabolism"

15:15-15:30: EJTEMM2018 Closing

Wednesday 6th December 2017

13:00-14:00: Lunch 

14:15-14:30
EJTEMM 2017 Opening

Session 1: Membranes, membrane components and membrane functions
Marta Pasenkiewicz-Gierula

14:30-15:10: Keynote speaker
Ole G. Mouritsen (University of Copenhagen, Denmark)
"Higher sterols - a prerequisite for higher life?"

15:10-15:50: Keynote speaker
W. Karol Subczynski (Medical College of Wisconsin, USA)
"Biological evolution selected membranes with a particular cholesterol content to perform certain functions in the cells of eukaryotic organisms"

15:50-16:20: Coffee break

Session 1, continued: Ole G. Mouritsen

16:20-17:00: Keynote speaker
Akihiro Kusumi (Okinawa Institute of Science and Technology, Japan)
"Signal transduction by transient molecular complexes: findings by single-molecule tracking"

17:00-17:30
Himanshu Khandelia (University of Southern Denmark, Denmark)
"About simulations of the Zika virus, and membrane bending by electrostatic potentials (fexo-electricty"

17:30-17:55
Dawid Przystupski (Wroclaw Medical University, Poland)
"Membranes protection by freezing medium in cells exposed to variable temperature, pressure, overload and radiation in the stratosphere"

Sponsor session: Anna Wisniewska-Becker

17:55-18:20
Jakub Nowak (NanoTemper Technologies)
"When protein matters"

18:30-19:45: Dinner

Poster Session

19:45-21:00: Students'/PhD students' poster competition 

Working meeting

20:15-21:00: EJTEMM Advisory Board Meeting

Thursday 7th December 2017

Session 2: Membrane organisation
Norbert Kucerka

09:00-09:40: Keynote speaker
Martin Hof (Czech Academy of Sciences, Czech Republic)
"Lipid driven anodomains are fluid"

09:40-10:20: Keynote speaker
Georg Pabst (University of Graz, Austria)
"Asymmetric membranes: The difference it makes"

10:20-10:45
Sahithya S. Iyer (Indian Institute of Science, India)
"Identifying liquid-liquid phase coexistence: Insights from local non-affine deformation and topological rearrangements"

10:45-11:00: Conference photography

11:00-11:15: Coffee break

Session 3: Lipid nanostructures
Alex Bunker

11:15-11:45
Anna Wisniewska-Becker (Jagiellonian University, Poland)
"Nanodiscs vs liposomes - which model of biological membranes is more relevant"

11:45-12:15
Bozena Milanovic (Jagiellonian University, Poland)
"Structural studies of nanodiscs from molecular dynamics and spectral simulations"

12:15-12:45
Waldemar Kulig (University of Helsinki, Finland)
"Presence of oxysterols affects permeability of lipid bilayers"

12:45-13:45
Agnieszka Olzynska (Czech Academy of Sciences, Czech Republic)
"How does the presence of oxysterol change biophysical properties of model membranes - experimental studies"

13:15-14:45: Lunch

Session 4 continuation: Lipid oxidised forms
Piotr Jurkiewicz, Lukasz Cwiklik

14:45-15:15
Mounir Tarek (University of Lorraine, France)
"Reactive oxygen species action on cell membranes: unraveling a potential mechanism of electroporation in the biological context using molecular simulations"

15:15-15:45
Lukasz Cwiklik (Czech Academy of Sciences, Czech Republic)
"Oxidized phospholipid membranes as seen via molecular simulations"

15:45-16:15
Piotr Jurkiewicz (Czec Academy of Sciences, Czech Republic)
"Oxidized phospholipid - fluoroescence spectroscopy"

16:15-16:35: Coffee break

Session 5: Membrane modifiers
Burkhard Bechinger

16:35-17:05
Norbert Kucerka (Comenius University, Slovakia)
"Interactions in the pre-AD mimicking model membranes"

17:05-17:35
Daniela Uhrikova (Comenius University, Slovakia)
"Divalent metal cations as a mediator of DNA-phospholipid bilayer binding"

17:35-18:05
Hector Martinez-Seara (Czech Academy of Sciences, Czech Republic)
"Determinants of sodium and calcium adsorption onto neutral lipid bilayers"

Conference Special
Karin Riske

18:05-18:30
Ole G. Mouritsen (University of Copenhagen, Denmark)
"The science of deliciousness"

19:30: Departure from Przegorzaly to market square

20:00-22:30: Banquet 

22:30-23:00: Return from market square to Przegorzaly

Friday 8th December 2017

Session 6: Diffusion of membrane components
Martin Hof

09:00-09:30
Ilpo Vattulainen (University of Helsinki, Finland)
"Diffusion of lipids and transmembrane proteins in membranes - from dilute conditions to crowding"

09:30-10:10
Gerald Kneller (University of Orleans/CNRS, France)
"Anomalous lateral diffusion of lipid molecules in lipid bilayers"

10:10-10:25: Coffee break

Session 5 continuation: Membrane modifiers
W. Karol Subczynski

10:25-10:55
Wieslaw Gruszecki (Maria Curie-Sklodowska University, Poland)
"Xanthophylls in membranes"

10:55-11:20
Inna Ermilova (Stockholm University, Sweden)
"Studying the behaviour of cholesterol in different phospholipid bilayers: combining classical molecular dynamics with 2-D metadynamics simulations on a microseconds time-scale"

Session 7: Membrane transport
Daniela Uhrikova 

11:20-11:50
Karin Riske (Universidade Federal de Sao Paulo, Brazil)
"Edge tension of anionic membranes"

11:50-12:20
Florent Di Meo (University of Limoges, France)
"Drug membrane permeation: Towards semi-quantitative structure permeation relationship"

12:20-12:35: Coffee break

Session 8: Methods
Patrick Trouillas

12:35-13:05
Stefan Knippenberg (Royal Institute of Technology, Sweden)
"Atomistic pictures of fluorescent probes in lipid bilayer membranes enhance lipid phase recognition through combined (non-) linear optical and fluorescence analyses"

13:05-13:30
Benjamin Chantemargue (University of Limoges, France)
"Exploration of landscapes of ABC membrane exporter"

13:30-13:55
M. Tarek Abdelwahab (Max Planck Institute for Polymer Research, Germany)
"Chemical compositions of ordered and disordered domains in phase-separated lipid membranes via CARS microsopy"

13:55-14:25: Closing ceremony

14:25-14:35: Announcement of the winners of the students' oral presentation and poster competition

14:35-16:00: Lunch

Wednesday 7th September 2016

14:00 – 15:00 registration in the lobby of the Faculty of Pharmacy at Odbojárov 10

15:00 – 15:15 welcome by Norbert Kučerka and Daniela Uhríková
Opening by the dean of Faculty of Pharmacy CU Pavel Mučaji

Session 1: Katerina Vavrova

15:15-16:00
John F. Nagle
"Mechanical and structural properties of lipid bilayers"

16:00-16:30: Coffee break

16:30-17:00
Burkhard Bechinger
"Biophysical investigations of Histidine-rich amphipathic peptides with a range of biological functions"

17:00-17:30
Thomas Hauss
"Lipid membrane structure and dynamics in the presence of Amyloid-beta peptide"

17:30-18:00
Maria Klacsova
"Nonlamellar lipid structures: effect of primary alkan-1-ols"

18:00-18:30
Olexander I. Ivankov
"Small angle scattering instrument YuMO"

18:30-20:00
Poster session and Welcome mixer
Meeting of the steering committee in parallel

Thursday 8th September 2016

Session 2: John F. Nagle

08:30-09:15: EBSA talk
Marta Pasenkiewicz-Gierula
"Profiles of the oxygen diffusion-concentration product across lipid bilayers: computer simulation vs. experiment"

09:15-10:00: EBSA student talk
Inna Ermilova
"SLipids force field: further extension and validation for polyunsaturated phospholipids"

10:00-10:30: Coffee break

10:30-11:00
Alex de Vries
"Gromos and Martini force fields for glycolipids"

11:00-11:30
Alexander Lyubartsev
"Bottom-up derived coarse-grain models for lipid bilayers simulations"

11:30-12:00
Stefan Knippenberg
"The use of DiI and Laurdan as optical probes in membranes"

12:00-12:30
Florent Di Meo
"Theoretical elucidation of drug-membrane interactions in passive permeation to active protein-mediated crossing"

12:30-14:00: Lunch break

Session 3: Sergio de Souza Funari

14:00-14:45: EBSA talk
Katerina Vavrova
"Models of the skin lipid barrier - from complexity to simplicity and back"

14:45-15:15: EBSA student competition
Lukas Opalka
"Human ultralong chain ceramides: synthesis and their role in the skin barrier"

15:15-15:45: EBSA student competition
Markéta Paloncýová
"Stratum corneum structure - insight from molecular simulations of bilayers and multilayers"

15:45-16:15: Coffee break

16:15-16:45
Karlo Komorowski
"SNARE-meidated membrane fusion intermediates studied by small-angle X-ray scattering"

16:45-17:15: EBSA student competition
Xiao Wu
"Interaction of beta-lapachone with lipids used in the formulation of siposomes for cancer therapy: experimental and theoretical approaches"

17:15-17:45
Lukas Sukenik
"The role of membrane receptors properties in the uptake of nanoparticles"

17:45-18:15: EBSA student competition
Tereza Gerguri
"Membrane nanodisc with protein fence"

19:00-22:00
Banquet at hotel Junior

Friday 9th September 2016

Session 4: Marta Pasenkiewicz-Gierula

08:30-09:15
Sergio de Souza Funari
"Additives (Urea and TMAO) on POPE and POPC membranes"

09:15-09:45
Alexander Bucsi
"Kinetics of DNA condensation with DPPC"

10:00-10:30: Coffee break

10:45-11:15
Jana Gaburjáková
"Towards predicting luminal Ca2+ binding sites on the cardiac ryanodine receptor"

11:15-11:45
Lubica Lacinová
"Modulation of Cav3.2 T-type calcium channel permeability by asparagine-linked glycosylation"

11:45-12:15: EBSA student competition
Lucia Lapinova
"Grina modulates G-protein-mediated inhibition of CaV2.2 calcium channels"

12:15-12:45
Michal Belicka
"Membrane domains properties influenced by their lipid architecture and ioinic composition of the aqueous phase"

12:45-13:00: Closing remarks
Norbert Kucerka and Daniela Uhrikova

13:00-14:00: Farewell lunch

Wednesday 30th September 2015

18h00: Registration

19h00:Dinner – OpenLab, Valhallavägen 79

Thursday 01 October

(OpenLab, Valhallavägen 79)

08h00: Registration

08h30-08h45: Opening: S. Knippenberg

Session 1, Chair: O. Edholm

08h45-09h20, Keynote 1:
N. Kucerka, “Lipid Structural Diversity: from SIMulation to EXPeriment and back”

09h20-09h55, Keynote 2:

I. Vattulainen, “The influential cholesterol – how membranes sense changes in cholesterol structure”

09h55-10h15:
A. Rabinovich, “Molecular dynamics simulations of membranes: bond orientation properties in lipid molecules”

10h15-10h35:
M. Lindén, “Anisotropic membrane curvature sensing by antibacterial peptides”

10h35-10h55: Coffee

Session 2, Chair: A. Girard-Egrot

10h55-11h30, Keynote 3:
B. C. Lagerholm, “Recent results of experimental measurements of lateral diffusion of phospholipids in live cells
by Single Particle Tracking and Stimulated Emission Depletion Fluorescence Correlation Spectroscopy”

11h30-11h50:
R. Vácha, “Influence of ligand distribution on nanoparticle uptake efficiency”

11h50-12h10:
B. Bechinger, “Histidine-rich designer peptides with PH-dependent membrane topology, antimicrobial, nucleic acid transfection and viral transduction capabilities”

12h10-13h30: Lunch
(Nymble, Drottning Kristinas väg 15)

Session 3, Chair: I. Parmryd

13h30-14h05, Keynote 4:
O. G. Mouritsen, “Active membranes”

14h05-14h40, Keynote 5:
P. Trouillas, “Molecular dynamic simulation of biological membranes: towards in silico pharmacology”

14h40-15h00:
N. Awasthi, “On the transition region of trans‐membrane pores”

15h00-15h20:
R. Šachl, “The oxidized phospholipids PazePC and PoxnoPC change Bax ability to induce pores in
mitochondrial membranes”

15h20-15h40: Coffee

Session 4, Chair: O. G. Mouritsen

15h40-16h15, Keynote 6:
I. Parmryd, “The role of actin filaments in creating order in the plasma membrane”

16h15-16h35:
G. Fabre, “Effect of membrane composition on the interaction of small molecules with bilayer membranes”

16h35-16h55:
L. Cwiklik, “Molecular-level organization of the tear film lipid layer”

16h55-17h15:
M. Paloncýová, “Estimation of skin permeability – simulation approaches”

17h15-18h30: Posters

19h00: Conference Dinner

(Syster O Bror, Drottning Kristinas Väg 24)

Friday 02 October

(OpenLab, Valhallavägen 79)

Session 5, Chair: B. Bechinger

08h30-09h05, Keynote 7:
M. Hof, “Sphingomyelin specific triggering of in-membrane oligomerization of b-amyloid(1-40) and the
inhibitory effect of monosialoganglioside GM1”

09h05-09h25:
A. Girard-Egrot, “New simple & versatile tethered phospholipid bilayers for membrane protein reincorporation”

09h25-09h45:
J. Kapla, “Molecular dynamics simulations and NMR spectroscopy studies of trehalose – lipid bilayer Systems”

09h45-10h05:
B. Chantemargue, “Human ABC transporter MRP4: construction of a model, transport cycle and drug efflux”

10h05-10h25:
R. Covino, “mga2 senses lipid saturation in yeast ER membranes by using a rotation-based mechanism”

10h25-10h45: Coffee

Session 6, Chair: A. Lyubartsev

10h45-11h20, Keynote 8:
M. Otyepka, “Positioning of microsomal CYPs and drugs in lipid bilayers”

11h20-11h40:
A. A. Gurtovenko, “Calcium‐triggered adsorption of DNA on zwitterionic phospholipid membranes: Insight
from MD simulations”

11h40-12h00:
N. A. Murugan, “Multiscale modeling approach for membrane probes”

12h00-12h10: closing remarks

12h10-13h30: Lunch
(OpenLab, Valhallavägen 79)

Wednesday 1 st October 2014

 12:00-18:00
Registration 

14:00 Opening keynote 

14:00-18:00 Discussion panel – Connecting people 

19:00 Dinner 

Thursday 2nd October 2014 

9:00 Agnès Girad-Egrot
Relevance of Langmuir Monolayers as Experimental Membrane Models for Deciphering the Interaction Mechanisms with Biological Membranes 

9:30 Véronique Rosilio
Organisation of POPC in Monolayers: Theoretical and Experimental Studies 

10:00 Alexander P. Lyurbartsev
Force Field Development for Atomistic and Coarse-Grained Simulations of Lipid Membranes 

10:30 coffee break 

11:00 Karel Berka
The Effects of Membrane Environment on Drug Penetration, Accumulation and Metabolism 

11:30 Burkhard Bechinger
Solid-State NMR for the Investigation of Membrane-Associated Polypeptides and Compounds 

12:00 Gabin Fabre
Positioning Drugs and Natural Compounds in Various Membrane Models: an Atomistic Description 

12:30 Patrick Trouillas
MEMbrane CROssing of drugs at the aTOMic scale: towards pharmacogenetic models 

13:00 lunch 

14:00 Lukasz Cwiklik
Interactions of Calcium Cations with Phospholipid Membranes 

14:30 Robert Vácha
Double-Belt a Novel Structure of Membrane Pore 

15:00 Martin Hof
Effect of Sphingomyelin and GM1 Clusters on Diffusion of Membrane Bound Beta-Amyloid Peptides 

15:30 coffee break 

16:00 Žofie Sovová
Ceramides Adopt Sponge Geometry in Liquid-Crystalline Phase 

16:30 Kateřina Vávrová
Very Long and Long Ceramides in the Skin Barrier Lipid Membranes 

17:00 Rainer Böckman
Membranes in Atomistic and Coarse-Grained Simulations 

17:30 Stefan Knippenberg
The BNP probe embedded in different membrane phases 

18:00 concluding remarks of the day 

19:00 dinner Moravská restaurace, Main Square (Horní náměstí) - close to the St. Trinity Column 

Friday 3 rd October 2014 

8:00 Discussion panel – Horizon2020 grant opportunities 

12:00 Concluding remarks 

Tuesday, October 1st

Welcome of participants

19:00 Welcome dinner at restaurant “Au Bureau”

Wednesday, October 2nd

Location of the meeting: Hotel “Royal Mercure Limousin”

08:30 Opening presentation

08:45 Hydration, mobility, aggregation, and nanodomain formation in model membranes studied by fluorescence

Martin Hof, J. Heyrovský Institute of Physical Chemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic

09:15 NMR spectroscopic approaches to determine the bilayer structure and alignment of peptides and small molecules. The amino-terminal membrane anchor of huntingtin as an example

Burkhard Bechinger, Evgeniy S. Salnikov, Christopher Aisenbrey, Matthias Michalek, Anna Itkin, University of Strasbourg/CNRS UMR7177, Institut de Chimie de Strasbourg, France

09:45 Stockholm Lipids: A Refined All-Atom Force Field for Biological Membranes

Joakim Jämbeck, Alexander P. Lyubartsev, Division of Physical Chemistry, Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden

10:15 Coffee break

10:45 Biomimetic membranes: tools for molecular interaction analysis

Ofelia Maniti, Samuel Rebaud, Joe Sarkis, Agnès Girard-Egrot, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, Université Lyon 1ICBMS, UMR CNRS 5246, Villeurbanne, France

11:15 Membrane transporters in pharmacology

Nicolas Picard, Pierre-André Billat, Inserm, UMR-S850, Université de Limoges, CHU de Limoges, France

11:45 Cytochromes P450 on Membranes

Karel Berka, Markéta Paloncýová, Pavel Anzenbacher, Michal Otyepka, Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacký University, Olomouc, Czech Republic

12:15 Lunch at the hotel

13:15 A blue BODIPY based lipid phase sensitive probe

Mihaela Bacalum, Lina Wang, Volker Leen, Peijia Yuan, N. Smisdom, Eduard Fron, Stefan Knippenberg, Gabin Fabre, Patrick Trouillas, David Beljonne, Wim Dehaen, Noel Boens, Marcel Ameloot, Service de Chimie des Matériaux Nouveaux, Université de Mons, Mons, Belgium; Biomedical Research Institute, Hasselt University, Diepenbeek, Belgium

13:45 Physicochemical approaches to tackle molecule/membrane interfacial interactions

Véronique Rosilio, Université Paris Sud 11, CNRS UMR 8612, Châtenay-Malabry, France

14:15 Free Energy Profiles of Drugs on Membranes – Prediction of Partitioning and permeation

Markéta Paloncýová, Gabin Fabre, Patrick Trouillas, Karel Berka, Michal Otyepka, Regional Centre of Advanced Technologies and Materials, Department of Physical Chemistry, Faculty of Science, Palacký University, Olomouc, Czech Republic

14:45 Coffee break

15:15 Characterization of the Interactions Between Exogenous Agents and Model Lipid Membranes on the Nanometer Scale

Karim El Kirat-Chatel, UMR CNRS 6600 Biomechanics and Bioengineering, Compiègne University of Technology (UTC), 60205 Compiègne Cedex, France

15:45 Molecular dynamic simulations of natural compounds interacting with membranes

Gabin Fabre, Karel Berka, Burkhard Bechinger, Roderich Süssmuth, Michal Otyepka, Patrick Trouillas, LCSN and Inserm UMR-S850, Faculté de Pharmacie, Université de Limoges, France

16:15 Round Table: Concluding remarks, discussions on collaborative projects and future of the action

20:00 Gastronomic dinner at restaurant “L’amphitryon”

Ales Iglic (Ljubljana)

Alex Bunker (Helsinki)

Alexander Lyubartsev (Stockholm)

Burkhard Bechinger (Strasbourg), https://rmnmc.chimie.unistra.fr/ 

Christopher Aisenbrey (Strasbourg)

Georg Pabst (Graz)

Gÿorgy Vamosi (Debrecen)

Hector Martinez-Seara (Prague)

Judith Peters (Grenoble), https://judith-peters.wixsite.com/presentation

Lukasz Cwiklik (Prague), http://cwiklik.net

Markéta Paloncýová (Olomouc)

Marta Pasenkiewicz-Gierula (Krakau)

Martin Hof (Prague)

Michal Otyepka (Olomouc)

Norbert Kucerka (Bratislava)

Peter Nagy (Debrecen), https://peternagygroup.hu/

Sandro Keller (Graz)

Silvio Osella (Warsaw)

Stefan Knippenberg (Hasselt, Chair EJTEMM), https://www.uhasselt.be/en/who-is-who/stefan-knippenberg

Veronika Kralj-Iglic (Ljubljana), https://www.lkbf.si/people/veronika-kralj-iglic